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In-vitro activity of flomoxef, a new oxacephem group antibiotic, against Nocardia in comparison with other cephalosporins
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In-vitro activity of flomoxef, a new oxacephem group antibiotic, against Nocardia in comparison with other cephalosporins
Katsukiyo Yazawaa, Yuzuru Mikamia,*, Jun Unoa, Kiyotaka Otozaia and Tadashi Araib
+ Author Affiliations

aDepartment of Experimental Chemotherapy, Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University 1–8–1, Inohana, Chiba, Japan (280)
bBiotherapy Research Association 1–20–6, Mukougaoka, Bunkyo-ku, Tokyo, Japan (113)
*Corresponding author
Received May 5, 1989.
Accepted July 17, 1989.
Abstract

The susceptibility of 113 strains of pathogenic Nocardia, N. asteroides. N.farcinica, N. nova, N. brasiliensis and N. otitidiscaviarum to a new oxacephem antibiotic flomoxef was determined by an agar dilution method in comparison with those of 13 other cephalosporins. Flomoxef was two to 50 times more active against these pathogenic Nocardia than other cephalopsorins tested. However, there were differences in susceptibility to this antibiotic among these Nocardia strains. N. asteroides was the most sensitive species, followed by N.farcinica and N. nova. N. brasiliensis was moderately sensitive and N. otitidiscaviarum was resistant.

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