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标题: The Carcinogenic Potency Database (CPDB)上千种基因毒性杂质研究汇总 [打印本页]

作者: 伴云 时间: 2014-11-11 12:39 PM
标题: The Carcinogenic Potency Database (CPDB)上千种基因毒性杂质研究汇总
The Carcinogenic Potency Database (CPDB)Lois Swirsky Gold, PhD, Director
Memorial of Lois Swirsky Gold

A Web page (Margin of Exposure) provides a broad perspective on possible cancer hazards from human exposures to chemicals that cause cancer in high dose rodent cancer tests. Exposures are given in graphic and table formats, including high historical exposures to workers, pharmaceuticals, natural chemicals in the average diet, air pollutants, food additives, and pesticide residues.

A supplement to the CPDB was added in August 2007, which includes results on 66 new chemicals and new results for 52 chemicals already in the CPDB. All Web pages on this Web site have been updated to reflect these additions, including plots, summary tables, and Excel files. Click here for a list of new chemicals and a list of earlier chemicals with new data.

The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals. The CPDB provides easy access to the bioassay literature, with qualitative and quantitative analyses of both positive and negative experiments that have been published over the past 50 years in the general literature through 2001 and by the National Cancer Institute/National Toxicology Program through 2004. The CPDB standardizes the diverse literature of cancer bioassays that vary widely in protocol, histopathological examination and nomenclature, and in the published author’s choices of what information to provide in their papers. Results are reported in the CPDB for tests in rats, mice, hamsters, dogs, and nonhuman primates.

For each experiment, information is included that is important in the interpretation of bioassays: species, strain, and sex of test animal; features of experimental protocol such as route of administration, duration of dosing, average daily dose-rate in mg/kg body weight/day, and duration of experiment; target organ, tumor type, and tumor incidence; carcinogenic potency (TD50) and its statistical significance; shape of the dose-response, author’s opinion as to carcinogenicity, and literature citation. The TD50, our numerical description of carcinogenic potency, is the daily dose-rate in mg/kg/body weight/day for life to induce tumors in half of test animals that would have remained tumor-free at zero dose. TD50 provides a standardized quantitative measure that can be used for comparisons and analyses of many issues in carcinogenesis. The range of TD50 values across chemicals that are rodent carcinogens is more than 100 million-fold.

结构式等见附件：

作者: mohu619 时间: 2014-11-11 01:10 PM
不错的东西。

作者: 朵朵7 时间: 2014-11-11 06:31 PM
好东东，谢谢分享

作者: heheniu312 时间: 2014-11-18 12:21 PM
谢谢分享！

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